Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach
نویسندگان
چکیده
منابع مشابه
Title Comparison of Disease and Drug Profiles Using Gene Set Enrichment Analysis
Description This package generates ranked lists of differential gene expression for either disease or drug profiles. Input data can be downloaded from Array Express or GEO, or from local CEL files. Ranked lists of differential expression and associated p-values are calculated using Limma. Enrichment scores (Subramanian et al. PNAS 2005) are calculated to a reference set of default drug or disea...
متن کاملPackage 'drugvsdisease' Title Comparison of Disease and Drug Profiles Using Gene Set Enrichment Analysis
Description This package generates ranked lists of differential gene expression for either disease or drug profiles. Input data can be downloaded from Array Express or GEO, or from local CEL files. Ranked lists of differential expression and associated p-values are calculated using Limma. Enrichment scores (Subramanian et al. PNAS 2005) are calculated to a reference set of default drug or disea...
متن کاملTitle Comparison of Disease and Drug Profiles Using Gene Set Enrichment Analysis
Description This package generates ranked lists of differential gene expression for either disease or drug profiles. Input data can be downloaded from Array Express or GEO, or from local CEL files. Ranked lists of differential expression and associated p-values are calculated using Limma. Enrichment scores (Subramanian et al. PNAS 2005) are calculated to a reference set of default drug or disea...
متن کاملImportance of collection in gene set enrichment analysis of drug response in cancer cell lines
Gene set enrichment analysis (GSEA) associates gene sets and phenotypes, its use is predicated on the choice of a pre-defined collection of sets. The defacto standard implementation of GSEA provides seven collections yet there are no guidelines for the choice of collections and the impact of such choice, if any, is unknown. Here we compare each of the standard gene set collections in the contex...
متن کاملNew Platforms For Drug Screening And Toxicology: Necessity Or Need?
The liver is the largest internal organ in the human body that is responsible for more than 500 vital functions, including biosynthesis of major plasma proteins, immunity against infectious pathogens, balancing energy metabolism and xenobiotics biotransformation (1). One of the main functions of the liver is an important role in drug metabolism (2). Since developing new drug compounds into mark...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2021
ISSN: 1471-2105
DOI: 10.1186/s12859-020-03929-0